Process Science
Compass can provide extensive experience in all areas of process science: process development, analysis and formulation.  Compass has a background spanning both development and manufacturing, resulting in a unique technical and operational skill set, with a solution oriented perspective on the following obstacles and challenges you may be facing:
Bioprocessing Strategy—
  • Risk Analysis;
  • Risk/Benefit Assessments;
  • Process Flow Diagrams;

Purification Development/Downstream Processing—

  • Protein Purification and Characterization;
  • Cell Separation and Sterile Filtration;
  • Ultrafiltration and Dafiltration (TFF), Concentration and Buffer Exchange;
  • Continuous Centrifugation;
  • Two-Phase Liquid-Liquid Extraction;
  • Precipitation;
  • Aseptic Processing for Cell-Based Therapies;
  • Aggregate Reduction.


Buffer preparation—


  • Column Packing;
  • Ion Exchange Chromatography;
  • Affinity Chromatography;
  • Size Exclusion Chromatography;
  • Hydrophobic Interaction Chromatography;
  • Reversed Phase Chromatography;
  • Preparative HPLC.

Product Characterization—

  • SDS-PAGE (1D and 2D);
  • IEF;
  • Capillary Electrophoresis;
  • HPLC (RP, IEC and SEC, including Light Scattering Detection);
  • Western Blots;
  • Aggregate Characterization;
  • Residual Host Cell Protein Determination;
  • Residual Protein-A Determination;

Formulation development—

Continuous Process Improvement (CIP)

  • Troubleshooting;
  • Efficiency;
  • Bottleneck Elimination;
  • Yield Increase;
  • Cost Reduction;
  • Gap analysis.

Technical development report writing—

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